Thriving in Uncertainty: A Guide to Growth in the Unknown By Jeff Karp

Life rarely follows a straight path. My own journey in science and innovation wasn’t planned from the start—it was driven by curiosity, taking one step at a time into the unknown. Every time I explored a new idea, even when it felt uncomfortable or uncertain, it was because I wanted to learn and discover something new. Starting something fresh often feels like stepping into unfamiliar territory, but curiosity turns that unknown into a chance for growth.

In my lab at Harvard Medical School, curiosity is the main thing that pushes us forward. We often dive into areas where we don’t have all the answers, like working on things such as bioinspired tissue glue that can seal holes in a beating heart, nasal sprays that fight viruses, or smart needles designed to deliver drugs for treating macular degeneration.

We ask questions like, “Who can we collaborate with to make this better?” As we explore new ideas, we actively seek out partners and collaborators who bring different perspectives and expertise. Together, we learn, adapt, and refine our approach, knowing that the best outcomes come from working with others. You don’t need all the answers—just the curiosity to find the right people, try new things, and learn through meaningful collaborations

Building Deeper Connections Through Curiosity
Curiosity isn’t just about your own journey—it also helps you connect more deeply with others. Start by using curiosity to strengthen your relationships. Asking thoughtful, open-ended questions can uncover hidden passions and interests in your friends or family, creating opportunities for shared adventures and deeper bonds

  • Ask About Hidden Dreams: “If you could spend a day doing anything you’ve always wanted to try, what would it be?” Their answer might lead to exploring pottery, trying salsa dancing, or even booking a spontaneous indoor skydiving session together.
  • Uncover Childhood Passions: “What’s something you loved as a kid but haven’t done in years?” This question could lead to fun activities like going bowling, hosting a painting night, vising an arcade, or stargazing on a clear evening
  • Explore Aspirations: “What’s a skill or hobby you’ve been wanting to try but haven’t yet?” You could join them in a beginner’s workshop—whether it’s baking sourdough bread, making kombucha, learning rock climb, or building a birdhouse from scratch.
  • Create a Shared Challenge: “What’s something we could try together that neither of us has done before?” You might enjoy challenges like tackling an escape room or even creating a bucket list together.
  • Find Shared Passions: “What’s your favorite way to spend a free afternoon?” Their answer might show a shared love of exploring art galleries or coffee shops, volunteering at animal shelters, or walking through new neighborhoods.

Every great idea starts with uncertainty, fueled by curiosity. When you follow your curiosity—whether about the world or the people around you—you open the door to growth, joy, and stronger connections. Let curiosity guide you to a life full of exciting discoveries and deeper bonds.

Why It Matters
Curiosity helps you build connections with others and discover new experiences. By exploring the unknown together, you create a sense of shared adventure that brings energy and excitement into your life. Asking questions not only leads to fun new activities but also strengthens relationships and sparks creativity.

Let curiosity be your guide—it will help you build stronger connections, find new opportunities, and enjoy moments of joy that you might have missed otherwise. Together, you can turn the unknown into a journey of discovery, illuminating your life with new possibilities.

LIT: Use Nature’s Playbook to Energize your Brain, Spark Ideas, and Ignite Action
by Jeff Karp (Harper Collins, 2024). Learn more: jeffkarp.com